North Queensland Toyota Cowboys second-rower John Bateman (illness) has been ruled out of Saturday's clash against the South Sydney Rabbitohs at Optus Stadium.
Jeremiah Nanai takes his place in the starting side, with Harrison Edwards added to the interchange.
Tom Duffy and Karl Lawton are the other two players to drop out of the 22-man squad named on Tuesday.
Saturday’s game kicks off at 3.30pm (5.30pm AEST).
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Cowboys team to play Rabbitohs:
2. Rob Derby
3. Jaxon Purdue
6. Tom Dearden (c)
9. Reece Robson
10. Jason Taumalolo
15. Jeremiah Nanai
12. Kai O’Donnell
13. Reuben Cotter (c)
Interchange
14. Sam McIntyre
16. Griffin Neame
17. Coen Hess
18. Harrison Edwards
Reserves
19. Zac Laybutt
22. Tom Mikaele
