North Queensland Toyota Cowboys Head Coach Todd Payten has made two major changes to his backline to replace injured five-eighth Tom Dearden.
Hamiso Tabuai-Fidow has been named at fullback for the first time since Round 4, with Scott Drinkwater moving to five-eighth.
It will mark Drinkwater’s first appearance in the No.6 jersey since Round 25 last season.
Luciano Leilua remains in the starting side after a brilliant 80-minute performance in the victory over the Warriors.
Tom Gilbert returns to the side on the interchange after missing the Warriors fixture because of a family issue.
Saturday’s game kicks off at 7.35pm.
>>> Payten on Dearden's injury, backline reshuffle and Leilua's form
Cowboys team to play Rabbitohs:
2. Kyle Feldt
4. Peta Hiku
7. Chad Townsend (c)
9. Reece Robson
10. Reuben Cotter
11. Luciano Leilua
12. Jeremiah Nanai
13. Jason Taumalolo (c)
Interchange
14. Tom Gilbert
15. Coen Hess
17. Griffin Neame
Reserves
18. Brendan Elliot
19. Tom Chester
20. Jake Granville
21. Riley Price
22. Ben Condon