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North Queensland Toyota Cowboys head coach Todd Payten has reduced his squad to 19 ahead of Saturday evening's clash with the Manly Sea Eagles at Queensland Country Bank Stadium.

Ben Hampton was ruled out on Friday morning, with 21-year-old Daejarn Asi taking his place in the centres. 

Prop Lachlan Burr is the other player to drop out of the 21-man squad named on Tuesday. 

Saturday’s game kicks off at 5.30pm.

>>> Payten: He's been our most consistent middle forward this season

Cowboys team to play Sea Eagles:

1.    Hamiso Tabuai-Fidow

2.    Kyle Feldt

3.    Valentine Holmes

19.  Daejarn Asi

5.    Murray Taulagi

6.    Scott Drinkwater

7.    Tom Dearden

8.    Coen Hess

9.    Reece Robson

10.  Jordan McLean

11.  Ben Condon

12.  Jeremiah Nanai

13.  Jason Taumalolo (C)

Interchange

14.  Jake Granville

15.  Heilum Luki

16.  Mitch Dunn

17.  Griffin Neame

Reserves

18.  Tom Gilbert

21.  Connelly Lemuelu