North Queensland Toyota Cowboys captain Jason Taumalolo is facing a fresh stint on the sideline after fracturing the opposite hand to the one he injured in March.
Taumalolo suffered the injury at training and is expected to be sidelined between 1-3 weeks.
Off-season recruit Lachlan Burr will start the game at lock, with Mitch Dunn coming onto the bench.
Esan Marsters is the other player to drop out of the 21-man squad named on Tuesday.
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Cowboys team to play Bulldogs:
2. Kyle Feldt
7. Ben Hampton
8. Coen Hess
9. Reece Robson
10. Jordan McLean
11. Shane Wright
12. Ben Condon
15. Lachlan Burr
Interchange
14. Jake Granville
16. Francis Molo
17. Corey Jensen
19. Mitch Dunn
Reserves
20. Peter Hola
21. Jake Clifford